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They are usually requested by practitioners and policy makers to aid in their decision-making. They also provide a useful way to identify the causal relationship between an intervention and its results. They should not, however be used to replace the need for explanation studies. The concept of pragmatism is controversial, and there are questions regarding whether pragmatic trials could be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for <a href="https://www.xuetu123.com/home.php?mod=space&uid=9721948">프라그마틱 무료게임</a> pragmatic trials.2 This tool attempted to define the elements of a pragmatic study that includes recruitment, design, delivery of the intervention, and follow-up. 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